By H. Maurice Goodman
Simple clinical Endocrinology, 3rd version offers up to date insurance of quickly unfolding advances within the figuring out of hormones interested in regulating so much elements of physically features. The dialogue specializes in molecular and mobile features of hormone creation and motion firmly rooted within the context of integrative body structure. subject matters are approached from the point of view of a physiologist with 4 a long time of educating experience.
This booklet is richly illustrated with either descriptive schematic diagrams and laboratory findings acquired in scientific experiences. all the 13 in-depth chapters starts off with an 'Overview' of the subject and ends with a 'Suggested studying' list.
* unmarried authorship offers continuity and consistency among chapters
* Richly illustrated with over two hundred illustrations
* IThirteen in-depth chapters incorporating the newest insights gleaned from speedily increasing genetic experiences of people and rodents
* writer has taught topic for over forty years
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Additional resources for Basic Medical Endocrinology, Third Edition
Hormone binding to the extracellular domain of the receptor activates protein tyrosine kinases that catalyze the phosphorylation of hydroxyl groups of tyrosine residues in the cytosolic portion of the receptor, in the associated kinase (autophosphorylation), or in other cytosolic proteins that complex with the phosphorylated receptor. The protein substrates for receptor-activated tyrosine kinases may have catalytic activity or may act as scaffolds to which other proteins are recruited and positioned so that enzymatic modifications are facilitated.
These hormones produce their effects by binding to receptors on the cell surface and rely on molecules on the cytosolic side of the membrane to convey the signal to the appropriate intracellular effector sites that bring about the hormonal response. The G-Protein-Coupled Receptors The most frequently encountered cell surface receptors belong to a very large superfamily of proteins that couple with guanosine nucleotide binding proteins (G-proteins) to communicate with intracellular effector molecules.
The most highly conserved region of these receptors is a stretch of about 65–70 amino acid residues that constitutes the DNA-binding domain. The hormone-binding domain, which is near the carboxyl terminus, also contains amino acid sequences that are necessary for activation of transcription. Between the DNA-binding domain and the amino terminus is the so-called hypervariable region, which, as its name implies, differs both in size and in amino acid sequence for each receptor. The steroid hormone receptors constitute a closely related group within the family.
Basic Medical Endocrinology, Third Edition by H. Maurice Goodman