New PDF release: Advances in Molecular and Cellular Endocrinology, Vol. 2

By Derek LeRoith

ISBN-10: 0762302925

ISBN-13: 9780762302925

Quantity 2 has inquisitive about features of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. moreover, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. ultimately, the "hot themes" comprise leptin and development issue signaling.

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Extra resources for Advances in Molecular and Cellular Endocrinology, Vol. 2

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1989). GH-R mRNA expression in rats is low at birth, but rises sharply at two to three weeks of age, reaching a plateau several weeks later. In chickens, hepatic GH-R mRNA appears on embryonic day 15, peaks by days 17-19, and declines on day 21, the day of hatching (Burnside and Cogburn, 1992). Approximately two weeks after birth, chicken hepatic GH-R mRNA levels begin to increase again, reaching a peak as the animal reaches mature body weight. The cloned prolactin receptor (PRL-R) is -30% identical to the GH-R, and both receptors are members of the cytokine receptor superfamily 38 MICHAEL I.

1994). Therefore, different segments of the intracellular region of the GH-R may be required for phosphorylation of different proteins. , 1995). , 1992; Winston and Bertics, 1992). , 1993). , 1994). , 1994). Figure 1 summarizes the structure-function studies discussed in this section. , 1994). Subsequently, different cytokine receptors were found to activate various STATs in response to ligand binding. To date, six STATs have been characterized and cloned (Ihle, 1996). These proteins comprise a related family that share --28 to 40% sequence identity in the first -700 amino acids, but differ widely at the COOH-terminus.

Rev. 12, 235-251. A. (1996). Characterization oflactogen receptor binding site 1 of human prolactin. J. Biol. Chem. 271, 14353-14360. , & Akira, S. (1994). Cytokine signal transduction. Cell 76, 253-262. , & Miyajima, A. (1994). Multimeric cytokine receptors. Trends Endocrinol. Metab. 5, 8-14. M. (1994). Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors. Protein Sci. 3, 1697-1705. A. (1994). Prolactin induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase.

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Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith


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