Download e-book for iPad: Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith

By Derek Leroith

ISBN-10: 0762301589

ISBN-13: 9780762301584

Traditionally the sphere of endocrine examine has continuously been on the vanguard of clinical endeavors. The investigators of those very important breakthroughs in examine were rewarded by way of quite a few Nobel awards. within the box of diabetes on my own, Nobel prizes were provided to researchers who chanced on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. no longer unusually, biomedical researchers have continually been attracted by means of the endocrine process and different related platforms of intercellular communique. during the last twenty years, endocrine study has built quickly and tailored smooth molecular and mobile biology strategies for its particular use. those alterations have allowed researchers within the box to keep up their facet. hence, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine issues. Our realizing of the law of gene expression has been drastically superior by means of molecular recommendations. In an try to carry investigators modern with the new advances during this exploding box we've got determined to post a chain entitled Advances in Molecular and mobile Endocrinology. the world over recognized investigators have agreed to take part and their contributions are preferred. quantity 1 has eager about points of the hypothalamic-pituitary axis together with GnRH and GH gene rules, molecular elements of insulin, insulin-like progress components and glucagon. moreover, reports at the lately cloned calcium receptor and steroid receptor interactions with DNA are awarded.

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Additional resources for Advances in Molecular and Cellular Endocrinology, Vol. 1

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B. Saunders, Philadelphia. L. (1991). Complex regulatory pathway of GnRH gene transcripts by forskolin, ionomycin and phorbol esters in the GT1 cell line. Soc. Neurosci. ). L. (1993). Transcriptional and post-transcriptional regulation of gonadotropin releasing hormone gene expression by the activation of protein kinase C pathway in a mouse hypothalamic GT1 cell line. Soc. Neurosci. ). L. (1994). Second messenger regulation of mouse gonadotropin-releasing hormone gene expression in immortalized mouse hypothalamic GTI-3 cells.

1995). GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers. J. Biol. Chem. 270, 1515-1520. L. (1994). Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone from the GTI-1 neuronal cell line. Endocrinology 134, 1782-1787. L. (1994). GATA-binding proteins regulate the human gonadotropin |174 gene in placenta and pituitary. Mol. Cell. Biol. 14, 5592-5602. , & Gruss, P. (1992). Mini-Oct and Oct-2c: Two novel, functionally diverse murine Oct-2 gene products are differentially expressed in the CNS.

1993). 0: A POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. Proc. Natl. Acad. Sci. USA 90, 10841-10845. R. (1993). Para-aoric splanchnopleura from ealy mouse embryos contains B la cell progenitors. Nature 364, 67-70. , & Vale, W. (1991). Activin-A modulates GnRH secretion from a GnRH-secreting neuronal cell line. Neuroendocr. 54, 373-377. L. (1994). Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-D, L-aspartate in the male rat.

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Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith


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