By Philip W. Harvey, David J. Everett, Christopher J. Springall
Despite being considered as the most typical toxicological goal within the endocrine procedure, the adrenal gland has usually been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes ideas to be had to ascertain adrenal endocrine disruption.
Examining present ideas and the most recent developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents details at the variety of substances and chemical substances that have an effect on adrenocortical functionality and indicates standardized techniques for in vivo and in vitro overview. This quantity additionally offers contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.
Adrenal Toxicology :
- reflects the key advancements revamped the earlier decade
- focuses at the most modern examine strategies, together with their makes use of and limitations
- provides an built-in method for adrenal toxicology evaluation
- identifies wisdom and information gaps, offering impetus for regulatory consideration
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Additional info for Adrenal Toxicology
In fact, Oskarsson et al. (2006) have compared the H295R cell line with normal adult human adrenal over a number of endpoints and reported good correlation of response, which was improved with the addition of forskolin to H295R cells, and this, therefore, also supports the H295R cell line as a model relevant for general human extrapolation. Related to this is the equally important consideration of multidrug resistance (MDR) proteins that act as chemical efflux pumps particularly in cancer cell lines (from which the H295R line is derived).
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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall