Download e-book for kindle: Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the most typical toxicological goal within the endocrine procedure, the adrenal gland has usually been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes ideas to be had to ascertain adrenal endocrine disruption.

Examining present ideas and the most recent developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents details at the variety of substances and chemical substances that have an effect on adrenocortical functionality and indicates standardized techniques for in vivo and in vitro overview. This quantity additionally offers contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the key advancements revamped the earlier decade
  • focuses at the most modern examine strategies, together with their makes use of and limitations
  • provides an built-in method for adrenal toxicology evaluation
  • identifies wisdom and information gaps, offering impetus for regulatory consideration

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Additional info for Adrenal Toxicology

Sample text

In fact, Oskarsson et al. (2006) have compared the H295R cell line with normal adult human adrenal over a number of endpoints and reported good correlation of response, which was improved with the addition of forskolin to H295R cells, and this, therefore, also supports the H295R cell line as a model relevant for general human extrapolation. Related to this is the equally important consideration of multidrug resistance (MDR) proteins that act as chemical efflux pumps particularly in cancer cell lines (from which the H295R line is derived).

J Endocrinol 2007; 195:459–472. Sanderson JT, Slobbe L, Lansbergen GW, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci 2001a; 61:40–48. Sanderson JT, Letcher RJ, Heneweer M, et al. Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect 2001b; 109:1027–1031.

Ecotoxicology 2006; 15: 83–96. Chandra AK, Chatterjee A, Ghosh R, et al. Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Reprod Toxicol 2007; 24:388– 396. 26 Harvey et al. Chang HW, Wu VC, Huang CY, et al. D4 Dopamine receptor enhances angiotensin-II stimulated aldosterone secretion through PKC and calcium signalling. Am J Physiol Endocrinol Metab 2008; 294:E622–629. Chen QM, Alexander D, Sun H, et al. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: Induction of antiapoptosis, antioxidant and detoxification genes.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


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